What Are Polynucleotides Made From?

Polynucleotides are fragments of DNA that are highly purified and derived from salmon or trout DNA. The treatment is sometimes misleadingly referred to as the "salmon sperm facial," but it contains neither sperm nor whole salmon. Instead, the DNA is extracted and purified using advanced techniques, ensuring it is safe, biocompatible, and highly effective for skin regeneration. At Wrinkless, I use Plinest with their HPT technology, which guarantees the purest form of polynucleotides available. Importantly, the fish are not harmed during the harvesting process, which may be a key consideration for vegans and ethically conscious patients.

The Role of Polynucleotides in Collagen Production

From the age of 30, the skin loses about 1% of its collagen each year, leading to thinning, laxity, and fine lines. Polynucleotides not only stimulate collagen production, but they also slow down collagen degradation thanks to their powerful antioxidant properties. This means that over time, collagen levels improve, resulting in stronger, firmer skin.

Since the skin under the eyes is the thinnest, this area benefits the most from polynucleotide treatments. However, they can be used anywhere on the body where there is skin, making them a versatile solution for overall skin rejuvenation..

Who Is Suitable for Polynucleotide Treatments?

Everyone is suitable for polynucleotide treatments. Younger patients will age better by having them than by not having them, as they help preserve collagen levels. Patients with existing skin laxity will see a visible improvement in elasticity and firmness over time.

A course of three treatments is the standard recommendation, with results developing gradually. Since collagen production takes time, full results typically become visible over 12 weeks. The number of treatments required and the extent of results can vary depending on age, general skin health, and lifestyle habits such as smoking and alcohol consumption, which impact the skin’s healing response.

What Benefits Can You Expect?

Unlike treatments that provide instant results, polynucleotides work gradually, with visible improvements developing over weeks to months. The key benefits include:

• Improved Skin Quality Over Time – Polynucleotides rejuvenate the skin at a cellular level, leading to healthier, more resilient skin over the long term.
  
• Increased Elasticity and Recoil – By stimulating collagen and elastin, polynucleotides help restore the skin’s natural bounce, making it firmer and more supple.
• No Change in Face Shape – Unlike fillers, which add volume, polynucleotides do not alter facial structure. Instead, they improve the skin itself, maintaining a natural and refreshed appearance.
  
• Absorption and Biodegradability – Polynucleotides do not linger in the skin indefinitely. Once injected, they are gradually absorbed and metabolised, leaving behind the benefits of their regenerative effects.
  

Is This Treatment Right for You?

Polynucleotides are an excellent option for those looking to improve skin quality rather than augment facial features. They are particularly beneficial for individuals experiencing early signs of ageing, skin laxity, or a loss of elasticity. Because they strengthen and fortify the skin, they are also ideal for patients who want to protect against future damage and maintain a youthful, healthy complexion.

Curious about polynucleotides and whether they’re right for you?

Book your consultation today, and let’s take the first step towards Wrinkless skin.